41 research outputs found
Improved setup for producing slow beams of cold molecules using a rotating nozzle
Intense beams of cold and slow molecules are produced by supersonic expansion
out of a rapidly rotating nozzle, as first demonstrated by Gupta and
Herschbach. An improved setup is presented that allows to accelerate or
decelerate cold atomic and molecular beams by up to 500 m/s. Technical
improvements are discussed and beam parameters are characterized by detailed
analysis of time of flight density distributions. The possibility of combining
this beam source with electrostatic fields for guiding polar molecules is
demonstrated
Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses.
Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune responses. Immune responses in survivors of Ebola virus (EBOV) and Sudan virus (SUDV) infections have provided the most insight, with T cell responses as well as detailed antibody responses having been characterized. Immune responses to Marburg virus (MARV), however, remain almost entirely uncharacterized. We report that immune responses in MARV survivors share characteristics with EBOV and SUDV infections but have some distinct differences. MARV survivors developed multivariate CD4+ T cell responses but limited CD8+ T cell responses, more in keeping with SUDV survivors than EBOV survivors. In stark contrast to SUDV survivors, rare neutralizing antibody responses in MARV survivors diminished rapidly after the outbreak. These results warrant serious consideration for any vaccine or therapeutic that seeks to be broadly protective, as different filoviruses may require different immune responses to achieve immunity
New filovirus disease classification and nomenclature
Filoviruses, the members of the family Filoviridae, are
currently classified into one proposed and five established
genera (Supplementary Table 1). Of the twelve
described filoviruses, six have been identified as aetiological
agents of naturally occurring human disease
outbreaks
Short communication: a cluster of Marburg virus disease involving an infant.
A noteworthy cluster of six cases of Marburg haemorrhagic fever (MHF) was identified in the Democratic Republic of Congo. One of the cases is the first infant Marburg fever patient ever documented. Three of six cases presented surprisingly mild symptoms. The results of epidemiological and virological investigations are compatible with person-to-person transmission through body fluids and with mother-to-child transmission while nurturing. The findings show that mild cases of MHF have to be expected during an outbreak and point out the difficulty to base patient management decisions on clinical case definitions alone